| Catalog No. | HB949016 |
| Host species | Human |
| Species reactivity | Human |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Clonality | Monoclonal |
| Isotype | IgG1-lambda |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| Target | ACVR2, ACTRIIA, ACTR-IIA, Activin receptor type IIA, ACVR2A, Activin receptor type-2A, ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin level | Please contact the lab for this information. |
| Expression system | Mammalian Cells |
| Accession | P27037 & Q13705 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternative name | BYM338, 1356922-05-8 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Research Grade Bimagrumab
Overview
Description
Bimagrumab (HB949016) is a research-grade recombinant antibody targeting ACVR2. Produced in mammalian cells with native-like glycosylation.
Highlights
- ●Research Grade — For PK/PD studies, assay development, and ADA research.
- ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Images
 SEC-HPLC |
SEC-HPLC detection for Research Grade Bimagrumab. |
 Bioactivity |
Detects ACVR2A in indirect ELISAs. |
 Flow Cytometry |
Flow-cytometry using anti-human ACVR2A antibody. Hela cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human ACVR2A monoclonal antibody (Catalog HB949016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer. |
 SDS-PAGE |
SDS-PAGE for Research Grade Bimagrumab |