Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO) (HF664016)

Name: Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO)
Brand: abinScience
SKU: HF664016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HF664016
Description	Garadacimab (HF664016) is a research-grade recombinant antibody targeting F12. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG4-lambda
Expression system	Mammalian cells
Clonality	Monoclonal
Target	F12, HAF, Hageman factor, Beta-factor XIIa part 2, Coagulation factor XII
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P00748
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CSL312, 2162134-62-3
Background	Coagulation factor XII (F12/Coagulationfactor XII) is a ~67 kDa protein. Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. 1. Naito, K. et al. (1991) The Journal of biological chemistry 266, 7353-8. PMID: 2019570 2. MacQuarrie, JL. et al. (2011) Blood 117, 4134-41. PMID: 21304106 3. Brunnée, T. et al. (1993) Blood 81, 580-6. PMID: 8427954
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

SEC-HPLC detection for Research Grade Garadacimab.
SDS-PAGE

SDS-PAGE for Research Grade Garadacimab

References

Datasheet

Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO).pdf

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Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO) (HF664016)

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