Anti-ADRM1 Polyclonal Antibody (HS705014)

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Precio(USD): $

Especificación:

50ug
100ug

Número:

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Vista general
Imágenes
Referencias
Datasheet

Vista general

Número de catálogo

HS705014

Descripción

Anti-ADRM1 Polyclonal Antibody (HS705014) is a rabbit polyclonal antibody detecting ADRM1 in ELISA, IHC, WB. Suitable for Bovine, Chicken, Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Bos taurus, Chicken, Human, Mouse, Rat, Xenopus tropicalis, Xenopus laevis

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Isotipo

IgG

Clonalidad

Polyclonal

Inmunógeno

E. coli - derived recombinant Human ADRM1 (Thr2-Asp407).

Objetivo

Adhesion-regulating molecule 1, ADRM1, GP110, Rpn13 homolog, 110 kDa cell membrane glycoprotein, hRpn13, Gp110, Proteasome regulatory particle non-ATPase 13, ARM-1, Proteasomal ubiquitin receptor ADRM1

Purificación

Purified by antigen affinity column.

Número de acceso

Q16186

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Proteasomal ubiquitin receptor ADRM1 is a ~42 kDa protein. Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation.

1. Jørgensen, JP. et al. (2006) Journal of molecular biology 360, 1043-52. PMID: 16815440

2. Yao, T. et al. (2006) Nature cell biology 8, 994-1002. PMID: 16906146

3. Hamazaki, J. et al. (2006) The EMBO journal 25, 4524-36. PMID: 16990800

4. Qiu, XB. et al. (2006) The EMBO journal 25, 5742-53. PMID: 17139257

5. Husnjak, K. et al. (2008) Nature 453, 481-8. PMID: 18497817

6. Jiao, L. et al. (2014) Protein & cell 5, 616-30. PMID: 24752541

7. Sahtoe, DD. et al. (2015) Molecular cell 57, 887-900. PMID: 25702870

8. Vander Linden, RT. et al. (2015) Molecular cell 57, 901-911. PMID: 25702872

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-ADRM1 polyclonal antibody at 1ug/mL on recombinant ADRM1 (Catalog No. HS705012).

Referencias

Datasheet

Anti-ADRM1 Polyclonal Antibody.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo