Purpose-Built for Bioanalysis Anti-idiotype antibodies specifically designed and validated for PK and ADA ELISA workflows — not repurposed research antibodies.
Broad Drug Target Coverage Catalog anti-Id antibodies against adalimumab, bevacizumab, trastuzumab, rituximab, infliximab, nivolumab, pembrolizumab, atezolizumab, durvalumab, and expanding.
Assay-Format Validated Validated for bridging ELISA, sandwich ELISA, MSD/ECL, and cell-based neutralizing antibody (NAb) assay formats with application data provided.
Custom Anti-Id Development End-to-end service from AtaGenix — immunization strategy, hybridoma screening, epitope binning, and GLP-compatible scale-up with full characterization.
Complete PK/ADA Reagent Sets Matched pairs of capture anti-Id, detection anti-Id, and drug calibrator proteins — streamline your assay development with one supplier.
What is an anti-idiotype antibody?
An anti-idiotype (anti-Id) antibody specifically recognizes the unique antigen-binding region (idiotype) of a therapeutic antibody. It is used as a surrogate positive control in ADA assays and as a calibrator or detection reagent in PK assays.
What assay formats do your anti-Id antibodies support?
Our anti-idiotype antibodies are validated for bridging ELISA (ADA screening/confirmation), sandwich ELISA (PK measurement), electrochemiluminescence (MSD), and cell-based neutralizing antibody (NAb) assay formats.
Can you develop custom anti-idiotype antibodies for my drug?
Yes. Our parent company AtaGenix provides end-to-end custom anti-idiotype antibody development — from immunization strategy through hybridoma screening, epitope characterization, and scale-up production with full QC documentation.
How are anti-idiotype antibodies used in PK vs ADA assays?
In PK assays, anti-Id antibodies serve as capture or detection reagents to quantify drug concentration in serum. In ADA assays, they act as surrogate positive controls that mimic patient anti-drug antibody responses for assay validation and cut-point determination.
What drug targets do you cover?
We offer catalog anti-idiotype antibodies against major biologic drugs including adalimumab, bevacizumab, trastuzumab, rituximab, infliximab, nivolumab, pembrolizumab, atezolizumab, and many more. Custom development is available for any therapeutic antibody.
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