Anti-BIN1 Polyclonal Antibody (HT430014)

Name: Anti-BIN1 Polyclonal Antibody
Brand: abinScience
SKU: HT430014
Price: 168 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD): $

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet

Vista general

Número de catálogo

HT430014

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Isotipo

IgG

Clonalidad

Polyclonal

Inmunógeno

E. coli - derived recombinant Human BIN1 (Met1-Ser276).

Objetivo

AMPHL, Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, BIN1

Purificación

Purified by antigen affinity column.

Número de acceso

O00499

RRID

Anti-BIN1 Polyclonal Antibody (abinScience Cat# HT430014, RRID:AB_3722916)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Myc box-dependent-interacting protein 1 (BIN1/Amphiphysin-II) is a ~64 kDa protein. Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates.

1. Wu, T. et al. (2014) PloS one 9, e93060. PMID: 24755653

2. Miyagawa, T. et al. (2016) Human molecular genetics 25, 2948-2958. PMID: 27179792

3. Sakamuro, D. et al. (1996) Nature genetics 14, 69-77. PMID: 8782822

4. Dräger, NM. et al. (2017) EMBO reports 18, 2051-2066. PMID: 28893863

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-BIN1 polyclonal antibody at 1ug/mL on recombinant BIN1 (Catalog No. HT430012).

Referencias

Datasheet

Anti-BIN1 Polyclonal Antibody.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo