Anti-Phospho-Tau (pT231/pS235) Antibody (SAA3.05) (HY086113)

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Numéro de catalogue

HY086113

Description

Anti-Phospho-Tau (pT231/pS235) Antibody (SAA3.05) [SAA3.05] (HY086113) is a mouse monoclonal antibody detecting pT231 in IHC, IP, WB. Suitable for Human.

Highlights

●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

IHC, IP, WB

Espèce hôte

Mouse

Isotype

IgG2a, kappa

ID de clone

SAA3.05

Clonalité

Monoclonal

Cible

MAPTL, Paired helical filament-tau, MTBT1, Microtubule-associated protein tau, TAU, Neurofibrillary tangle protein, MAPT, PHF-tau, Tau 231, pT231

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P10636

RRID

Anti-Phospho-Tau (pT231/pS235) Antibody (SAA3.05) (abinScience Cat# HY086113, RRID:AB_3725728)

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Microtubule-associated protein tau (P-Tau) is a ~78 kDa protein. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

1. Yoshida, H. et al. (2012) Journal of neurochemistry 120, 165-76. PMID: 21985311

2. Sandberg, A. et al. (2020) Neurobiology of disease 146, 105079. PMID: 32961270

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Phospho-Tau (pT231/pS235) Antibody (SAA3.05).

Reférences

Fiche technique

Anti-Phospho-Tau (pT231/pS235) Antibody (SAA3.05).pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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