Anti-HCMV/HHV5 HHRF3/US28 Nanobody (SAA1107) (VK595033)

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Aperçu

Numéro de catalogue

VK595033

Description

Anti-HCMV/HHV5 HHRF3/US28 Nanobody (SAA1107) [SAA1107] (VK595033) is a alpaca monoclonal antibody detecting HHRF3 in ELISA.

Reactivité des espèces

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

Applications

ELISA

Espèce hôte

Alpaca

Isotype

VHH-8His-Cys-tag

ID de clone

SAA1107

Clonalité

Monoclonal

Cible

G-protein coupled receptor homolog US28, HHRF3, US28

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by Nickel column.

Numéro d'accès

P69332

RRID

Anti-HCMV/HHV5 HHRF3/US28 Nanobody (SAA1107) (abinScience Cat# VK595033, RRID:AB_3726822)

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

G-protein coupled receptor homolog US28 (HHRF3) is a ~41 kDa protein. Viral chemokine receptor that plays a critical role in viral pathogenesis, mediating several processes such as cellular migration, differentiation, transformation, and viral latency and reactivation. Binds to a great number of different CC-chemokines including CCL5/RANTES, CCL2/MCP-1, CCL3/MIP-1-alpha as well as CX3CL1/Fractalkine. Transduces signals resulting in the activation of MAP kinase signaling pathways and augmentation of intracellular calcium ion levels, leading to alterations in chemotactic behavior of vascular smooth muscle cells and macrophages. The US28 receptor also exhibits high levels of agonist-independent signaling activity and agonist-independent endocytosis. Interacts with the host Gi complex without activating it, thereby probably interfering with the chemokine-Gi signaling.

1. Burg, JS. et al. (2015) Science (New York, N.Y.) 347, 1113-7. PMID: 25745166

2. Kuhn, DE. et al. (1995) Biochemical and biophysical research communications 211, 325-30. PMID: 7540006

3. Gao, JL. et al. (1994) The Journal of biological chemistry 269, 28539-42. PMID: 7961796

4. Casarosa, P. et al. (2001) The Journal of biological chemistry 276, 1133-7. PMID: 11050102

5. Tsutsumi, N. et al. (2022) Science advances 8, eabl5442. PMID: 35061538

6. Maassen, F. et al. (2025) eLife 14. PMID: 40608405

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-HCMV/HHV5 HHRF3/US28 Nanobody (SAA1107)

Reférences

Fiche technique

Anti-HCMV/HHV5 HHRF3/US28 Nanobody (SAA1107).pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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