Anti-HPV16 E6/Protein E6 Antibody (SAA2275) (VK451033)

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50ug
100ug
1mg

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Numéro de catalogue

VK451033

Description

Anti-HPV16 E6/Protein E6 Antibody (SAA2275) [SAA2275] (VK451033) is a mouse monoclonal antibody detecting Protein E6 in ELISA.

Reactivité des espèces

Human papillomavirus type 16

Applications

ELISA

Espèce hôte

Mouse

Isotype

VHH-mFc

ID de clone

SAA2275

Clonalité

Monoclonal

Cible

E6, Protein E6

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>90% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P03126

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Protein E6 is a ~19 kDa protein. Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).

Note

For research use only.

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