Anti-Human CD279/PDCD1/PD1 & VEGF Bispecific Antibody (SSGJ-707) (HS870023)

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Precio(USD): $

Especificación:

50ug
100ug
1mg

Número:

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Vista general
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Referencias
Datasheet

Vista general

Número de catálogo

HS870023

Descripción

Anti-Human CD279/PDCD1/PD1 & VEGF Bispecific Antibody (SSGJ-707) [SSGJ-707] (HS870023) is a human monoclonal antibody detecting L-VEGF in ELISA, FACS, Functional assay. Suitable for Human.

Highlights

●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, FACS, Functional assay

Especie huésped

Human

Isotipo

IgG4, kappa-Fab

ID de clon

SSGJ-707

Clonalidad

Monoclonal

Objetivo

Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1, Vascular endothelial growth factor A long form, L-VEGF, Vascular permeability factor, VPF, N-VEGF, VEGFA, VEGFA, VEGF

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q15116, P15692

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Programmed cell death protein 1 (PDL1 & VEGF) is a ~31 kDa protein. Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with TCR-CD3 in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta.

1. Fife, BT. et al. (2011) Annals of the New York Academy of Sciences 1217, 45-59. PMID: 21276005

2. Bardhan, K. et al. (2019) Scientific reports 9, 17252. PMID: 31754127

3. Patsoukis, N. et al. (2020) Communications biology 3, 128. PMID: 32184441

4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329

5. Zak, KM. et al. (2015) Structure (London, England : 1993) 23, 2341-2348. PMID: 26602187

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-Human CD279/PDCD1/PD1 & VEGF Bispecific Antibody (SSGJ-707).pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo