



| Numéro de catalogue | VK632066 |
|---|---|
| Description |
Research Grade Rafivirumab (VK632066) is a canis monoclonal antibody detecting Glycoprotein in ELISA, FACS, Functional assay, Research in vivo. Suitable for Rabies virus (RABV).
Highlights
|
| Reactivité des espèces | Rabies virus (RABV) |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Espèce hôte | Canis |
| Isotype | IgG2a, kappa |
| Clonalité | Monoclonal |
| Cible | Glycoprotein, G |
| Niveau d'endotoxines | < 10 EU/mg |
| Pureté | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Numéro d'accès | O92284 |
| Forme | Liquid |
| Tampon de stockage | 0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Contexte | Glycoprotein (glycoprotein G) is a ~58 kDa protein. Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. |
| Note | For research use only. |

SDS-PAGE for Research Grade Rafivirumab

Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant Rabies virus/RABV G/Glycoprotein(Catalog No: VK632012)
Lane 2: negative control
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