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Anti-Human TNFa/TNF-alpha Antibody (SAA2507) (HF879113)

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Anti-Human TNFa/TNF-alpha Antibody (SAA2507)

Anti-Human TNFa/TNF-alpha Antibody (SAA2507)

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Спецификация:

20ug
50ug
100ug
1mg

Количество:

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Каталожный номер	HF879113
Описание	Anti-Human TNFa/TNF-alpha Antibody (SAA2507) [SAA2507] (HF879113) is a human monoclonal antibody detecting TNF-alpha in ELISA. Suitable for Human.
Реактивность видов	Human
Применения	ELISA
Хозяинский вид	Human
Изотип	Fab - G1 - kappa
ID клона	SAA2507
Клоональность	Monoclonal
Цель	C-domain 1, C-domain 2, Cachectin, ICD1, ICD2, Intracellular domain 1, Intracellular domain 2, N-terminal fragment, NTF, TNF, TNF-a, TNF-alpha, TNFA, TNFSF2, Tumor necrosis factor, Tumor necrosis factor ligand superfamily member 2, Tumor necrosis factor, membrane form, Tumor necrosis factor, soluble form
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P01375
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Tumor necrosis factor (TNFα) is a ~25 kDa protein. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. 1. Nie, H. et al. (2013) Nature medicine 19, 322-8. PMID: 23396208 2. Friedmann, E. et al. (2006) Nature cell biology 8, 843-8. PMID: 16829952 3. Jinesh G, G. et al. (2012) Journal of leukocyte biology 92, 233-44. PMID: 22517918 4. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819
Примечание	For research use only

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SDS-PAGE

SDS-PAGE for Anti-Human TNFa/TNF-alpha Antibody (SAA2507)

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Anti-Human TNFa/TNF-alpha Antibody (SAA2507).pdf

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Anti-Human TNFa/TNF-alpha Antibody (SAA2507)