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Anti-Human TNFa/TNF-alpha Antibody (SAA2509) (HF879133)

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Anti-Human TNFa/TNF-alpha Antibody (SAA2509)

Anti-Human TNFa/TNF-alpha Antibody (SAA2509)

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50ug
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1mg

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Datasheet

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Número de catálogo	HF879133
Descripción	Anti-Human TNFa/TNF-alpha Antibody (SAA2509) [SAA2509] (HF879133) is a human monoclonal antibody detecting TNF-alpha in ELISA. Suitable for Human.
Reactividad de especies	Human
Aplicaciones	ELISA
Especie huésped	Human
Isotipo	Fab - G1 - kappa
ID de clon	SAA2509
Clonalidad	Monoclonal
Objetivo	C-domain 1, C-domain 2, Cachectin, ICD1, ICD2, Intracellular domain 1, Intracellular domain 2, N-terminal fragment, NTF, TNF, TNF-a, TNF-alpha, TNFA, TNFSF2, Tumor necrosis factor, Tumor necrosis factor ligand superfamily member 2, Tumor necrosis factor, membrane form, Tumor necrosis factor, soluble form
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P01375
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Tumor necrosis factor (TNFα) is a ~25 kDa protein. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. 1. Nie, H. et al. (2013) Nature medicine 19, 322-8. PMID: 23396208 2. Friedmann, E. et al. (2006) Nature cell biology 8, 843-8. PMID: 16829952 3. Jinesh G, G. et al. (2012) Journal of leukocyte biology 92, 233-44. PMID: 22517918 4. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819
Nota	For research use only

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human TNFa/TNF-alpha Antibody (SAA2509)

Referencias

Datasheet

Anti-Human TNFa/TNF-alpha Antibody (SAA2509).pdf

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Anti-Human TNFa/TNF-alpha Antibody (SAA2509)