Anti-Human Abeta42/Beta-APP42 Antibody (21F12) (HP849013)

Fiche technique Partager le produit Copier les informations

Prix(USD) : $

Spécification :

20ug
50ug
100ug
1mg

Nombre :

Contactez-nous

Aperçu
Images
Reférences
Fiche technique

Aperçu

Numéro de catalogue

HP849013

Description

Anti-Human Abeta42/Beta-APP42 Antibody (21F12) [21F12] (HP849013) is a mouse monoclonal antibody detecting Beta-APP42 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Mouse

Isotype

IgG1

ID de clone

21F12

Clonalité

Monoclonal

Cible

Abeta42, Beta-APP42, Amyloid-beta protein 42, amyloid beta A4 precursor protein, Amyloid-beta A4 protein

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P05067

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Amyloid-beta precursor protein (Abeta 42/Beta-APP 42) is a ~86 kDa protein. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP.

1. Baumkötter, F. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 11159-72. PMID: 25122912

2. Satpute-Krishnan, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 16532-7. PMID: 17062754

3. Seamster, PE. et al. (2012) Physical biology 9, 055005. PMID: 23011729

Note

For research use only.

Images

Bioactivity

SEC-HPLC detection for Anti-Human Abeta42/Beta-APP42 Antibody (21F12).
SDS-PAGE

SDS-PAGE for Anti-Human Abeta42/Beta-APP42 Antibody (21F12).