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Anti-Human TrkB /NTRK2 Antibody (SAA0477), APC (HS892137)

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Каталожный номер	HS892137
Описание	Anti-Human TrkB /NTRK2 Antibody (SAA0477), APC [SAA0477] (HS892137) is a mouse monoclonal antibody detecting NTRK2 in ELISA, FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Реактивность видов	Human
Применения	ELISA, FCM
Хозяинский вид	Mouse
Изотип	IgG2a, kappa
ID клона	SAA0477
Конъюгация	APC
Клоональность	Monoclonal
Цель	Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB, TRKB, NTRK2, Tropomyosin-related kinase B, BDNF/NT-3 growth factors receptor, Trk-B
Уровень эндотоксинов	Please contact with the lab for this information.
Номер доступа	Q16620
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	BDNF/NT-3 growth factors receptor (TrkB/NTRK2) is a ~91 kDa protein. Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. 1. Yeo, GS. et al. (2004) Nature neuroscience 7, 1187-9. PMID: 15494731 2. Haniu, M. et al. (1995) Archives of biochemistry and biophysics 322, 256-64. PMID: 7574684
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human TrkB /NTRK2 Antibody (SAA0477), APC.pdf

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Anti-Human TrkB /NTRK2 Antibody (SAA0477), APC