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Anti-Human CD19 Antibody (HD37), PE (HB996527)

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Anti-Human CD19 Antibody (HD37), PE

Anti-Human CD19 Antibody (HD37), PE

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100T

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Aperçu

Numéro de catalogue	HB996527
Description	Anti-Human CD19 Antibody (HD37), PE [HD37] (HB996527) is a mouse monoclonal antibody detecting CD19 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Mouse
Isotype	IgG1, kappa
ID de clone	HD37
Conjugaison	PE
Clonalité	Monoclonal
Cible	CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4
Niveau d'endotoxines	Please contact with the lab for this information.
Numéro d'accès	P15391
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	B-lymphocyte antigen CD19 is a ~61 kDa protein. Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. CD19 is the therapeutic target of tafasitamab (Monjuvi). 1. Vanshylla, K. et al. (2018) Scientific reports 8, 4244. PMID: 29523808 2. Carter, RH. et al. (1992) Science (New York, N.Y.) 256, 105-7. PMID: 1373518 3. van Zelm, MC. et al. (2006) The New England journal of medicine 354, 1901-12. PMID: 16672701 4. de Rie, MA. et al. (1989) Cellular immunology 118, 368-81. PMID: 2463100 5. Wang, Y. et al. (2002) Immunity 17, 501-14. PMID: 12387743 6. Sato, S. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 159, 3278-87. PMID: 9317126 7. Buhl, AM. et al. (1997) The Journal of experimental medicine 186, 1897-910. PMID: 9382888
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

Images

Flow Cytometry

Flow-cytometry using PE anti-human CD19 antibody. Raji cells were stained with an irrelevant antibody (Green Histogram) or a PE anti-human CD19 antibody monoclonal antibody (Catalog # HB996527, Red Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

Reférences

Fiche technique

Anti-Human CD19 Antibody (HD37), PE.pdf

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Anti-Human CD19 Antibody (HD37), PE