Research Grade Datopotamab (HY373026)

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100ug
1mg

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Aperçu

Numéro de catalogue	HY373026
Description	Datopotamab (HY373026) is a research-grade recombinant antibody targeting Pancreatic carcinoma marker protein GA733-1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Humanized
Isotype	IgG1-kappa
Système d'expression	Mammalian Cells
Clonalité	Monoclonal
Cible	Pancreatic carcinoma marker protein GA733-1, Tumor-associated calcium signal transducer 2, M1S1, TROP2, TACSTD2, Cell surface glycoprotein Trop-2, GA733-1, Membrane component chromosome 1 surface marker 1
Niveau d'endotoxines	Please contact the lab for this information.
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P09758
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Noms alternatifs	DS-1062, DS-1062a, Datopotamabderuxtecan, 2267989-53-5
Contexte	Tumor-associated calcium signal transducer 2 (TACSTD2/TROP2) is a ~35 kDa protein. May function as a growth factor receptor. TACSTD2 is the therapeutic target of sacituzumab govitecan (Trodelvy).
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

Detects Human TROP2 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Datopotamab.
Flow CytoMetry

Flow-cytometry using anti-human TACSTD2 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human TACSTD2 monoclonal antibody (Catalog: HY373026) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
Western blot

Western blot analysis was performed using anti-TACSTD2/TROP2 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human TACSTD2/TROP2 (Catalog No: HY373011)
Flow cytometry

Flow-cytometry using FITC anti-human TACSTD2 antibody. Hela cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human TACSTD2 monoclonal antibody (Catalog HY373026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry

Flow-cytometry using FITC anti-human TACSTD2 antibody. MCF7 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human TACSTD2 monoclonal antibody (Catalog HY373026, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.