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Research Grade Anti-Human TREM2 Antibody (AL2p-58) (HV166026)

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Research Grade Anti-Human TREM2 Antibody (AL2p-58)

Research Grade Anti-Human TREM2 Antibody (AL2p-58)

Research Grade Anti-Human TREM2 Antibody (AL2p-58)

Research Grade Anti-Human TREM2 Antibody (AL2p-58)

Research Grade Anti-Human TREM2 Antibody (AL2p-58)

Research Grade Anti-Human TREM2 Antibody (AL2p-58)

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Spécification :

100ug
1mg

Nombre :

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Aperçu

Numéro de catalogue	HV166026
Description	Anti-Human TREM2 Antibody (AL2p-58) (HV166026) is a research-grade recombinant antibody targeting Triggering receptor expressed on myeloid cells 2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Isotype	IgG1
ID de clone	AL2p-58
Système d'expression	Mammalian Cells
Clonalité	Monoclonal
Cible	Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2, TREM-2, TREM2
Niveau d'endotoxines	Please contact the lab for this information.
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q9NZC2
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Contexte	Triggering receptor expressed on myeloid cells 2 (TREM2) is a ~25 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin. 1. Bouchon, A. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4991-5. PMID: 10799849 2. Yeh, FL. et al. (2016) Neuron 91, 328-40. PMID: 27477018 3. Zhao, Y. et al. (2018) Neuron 97, 1023-1031.e7. PMID: 29518356 4. Sudom, A. et al. (2018) The Journal of biological chemistry 293, 12634-12646. PMID: 29794134 5. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881 6. Filipello, F. et al. (2018) Immunity 48, 979-991.e8. PMID: 29752066 7. Bouchon, A. et al. (2001) The Journal of experimental medicine 194, 1111-22. PMID: 11602640 8. Paloneva, J. et al. (2003) The Journal of experimental medicine 198, 669-75. PMID: 12925681
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human TREM2 Antibody (AL2p-58)
Bioactivity

Detects recombinant human TREM2-SUMO (Catalog No: HV166032) in indirect ELISA
Western blot

Western blot analysis was performed using anti-TREM2 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human TREM2 (Catalog No: HV166032)
Lane 2: negative control

Reférences

Fiche technique

Research Grade Anti-Human TREM2 Antibody (AL2p-58).pdf

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Research Grade Anti-Human TREM2 Antibody (AL2p-58)