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Research Grade Anti-Human CD18/ITGB2 (YFC51.1) (HY378036)

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Research Grade Anti-Human CD18/ITGB2 (YFC51.1)

Research Grade Anti-Human CD18/ITGB2 (YFC51.1)

Precio(USD): $

Especificación:

100ug
1mg

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Datasheet

Vista general

Número de catálogo	HY378036
Descripción	Anti-Human CD18/ITGB2 (YFC51.1) (HY378036) is a research-grade recombinant antibody targeting CD18. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Humanized
Isotipo	IgG1-kappa slience
ID de clon	YFC51.1
Sistema de expresión	Mammalian Cells
Clonalidad	Monoclonal
Objetivo	Complement receptor C3 subunit beta, Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta, Integrin beta-2, MFI7, CD18, ITGB2
Nivel de endotoxinas	Please contact the lab for this information.
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P05107
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Fondo	Integrin beta-2 (CD18/ITGB2) is a ~84 kDa protein. Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3. Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. 1. de Fougerolles, AR. et al. (1991) The Journal of experimental medicine 174, 253-67. PMID: 1676048 2. Kristóf, E. et al. (2013) Apoptosis : an international journal on programmed cell death 18, 1235-51. PMID: 23775590 3. Lacouture, C. et al. (2024) Nature communications 15, 407. PMID: 38195629 4. Swaim, CD. et al. (2017) Molecular cell 68, 581-590.e5. PMID: 29100055 5. Van der Vieren, M. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 163, 1984-90. PMID: 10438935 6. Van der Vieren, M. et al. (1995) Immunity 3, 683-90. PMID: 8777714 7. Grayson, MH. et al. (1998) The Journal of experimental medicine 188, 2187-91. PMID: 9841932 8. Barber, DF. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 3653-9. PMID: 15356110 9. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992 10. Bai, M. et al. (2017) Blood 130, 2092-2100. PMID: 28807980
Nota	For research use only. Not suitable for clinical or therapeutic use.

Imágenes

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD18/ITGB2 (YFC51.1).

Referencias

Datasheet

Research Grade Anti-Human CD18/ITGB2 (YFC51.1).pdf

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Research Grade Anti-Human CD18/ITGB2 (YFC51.1)