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Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229) (VK565566)

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Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)

Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)

Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)

Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)

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Spécification :

100ug
1mg

Nombre :

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Aperçu

Numéro de catalogue	VK565566
Description	Anti-SARS-CoV-2 RBD Antibody (VIR-7229) (VK565566) is a research-grade recombinant antibody targeting Receptor-Binding Domain. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	SARS-CoV-2
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Isotype	IgG1-kappa
ID de clone	VIR-7229
Système d'expression	Mammalian Cells
Cible	Receptor-Binding Domain, RBD, Spike glycoprotein, S glycoprotein, Peplomer protein, Spike protein S1, S
Niveau d'endotoxines	Please contact the lab for this information.
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P0DTC2
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Noms alternatifs	VIR-7229, VIR7229, VIR7229
Contexte	Spike glycoprotein (RBD) is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 1. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8. PMID: 32142651 2. Walls, AC. et al. (2020) Cell 181, 281-292.e6. PMID: 32155444 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 33607086 4. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 34561887 5. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 32075877 6. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 32221306 7. Wang, J. et al. (2021) Cell discovery 7, 119. PMID: 34903715 8. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 36779763 9. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 33082294 10. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)
Western blot

Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant SARS-CoV-2 RBD(Catalog No: VK565131)
Lane 2: negative control

Reférences

Fiche technique

Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229).pdf

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Research Grade Anti-SARS-CoV-2 RBD Antibody (VIR-7229)