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| カタログ番号 | HP116014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human RAB1B (Met1-Gly176). | ||||||||
| ターゲット | RAB1B, Ras-related protein Rab-1B | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H0U4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ras-related protein Rab-1B (RAB1B) is a ~22 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. 1. Zoppino, FC. et al. (2010) Traffic (Copenhagen, Denmark) 11, 1246-61. PMID: 20545908 2. Overmeyer, JH. et al. (1998) Molecular biology of the cell 9, 223-35. PMID: 9437002 3. Gavriljuk, K. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 21348-53. PMID: 23236136 4. Aizawa, M. et al. (2015) The Journal of biological chemistry 290, 22250-61. PMID: 26209634 | ||||||||
| 注意事項 | For research use only. |
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