Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses

10.1126/sciadv.adl1122

Affiliations
Federica Vecchio, Alexia Carré, Daniil Korenkov, Zhicheng Zhou, Paola Apaolaza, Soile Tuomela, Orlando Burgos-Morales, Isaac Snowhite, Javier Perez-Hernandez, Barbara Brandao, Georgia Afonso, Clémentine Halliez, John Kaddis, Sally C Kent, Maki Nakayama, Sarah J Richardson, Joelle Vinh, Yann Verdier, Jutta Laiho, Raphael Scharfmann, Michele Solimena, Zuzana Marinicova, Elise Bismuth, Nadine Lucidarme, Janine Sanchez, Carmen Bustamante, Patricia Gomez, Soren Buus, Sylvaine You, Alberto Pugliese, Heikki Hyoty, Teresa Rodriguez-Calvo, Malin Flodstrom-Tullberg, Roberto Mallone

DOI: 10.1126/sciadv.adl1122

Abstract
Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β cell autoimmunity and type 1 diabetes. We investigated how CVB affects human β cells and anti-CVB T cell responses. β cells were efficiently infected by CVB in vitro, down-regulated human leukocyte antigen (HLA) class I, and presented few, selected HLA-bound viral peptides. Circulating CD8

Keywords
CD8，INF-α2a，T cell

関連製品

カタログ番号	製品名	説明	ターゲット
HF565010	IFN-α2a	InVivoMAb Anti-Human IFNA1/Interferon alpha-D (Iv0036) [Iv0036] (HF565010) is a human monoclonal antibody detecting LeIF D in ELISA, FCM, Neutralization. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.	LeIF D, Interferon alpha-1/13, IFNA1, Interferon alpha-D, IFN-alpha-1/13, IFN-Alpha, IFNA

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Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses

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