The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromes

10.1038/s44321-024-00176-1

Affiliations
Cristina Alarcón-Vila, Laura Hurtado-Navarro, Sandra V Mateo, Alejandro Peñín-Franch, Carlos M Martínez, Cristina Molina-López, María C Baños, Ana I Gómez, Javier Gómez-Román, Alberto Baroja-Mazo, Juan I Arostegui, Natalia Palmou-Fontana, Juan J Martínez-García, Pablo Pelegrin

DOI: 10.1038/s44321-024-00176-1

Abstract
In this Correspondence, P. Pelegrin and colleagues found that the deposition of amyloid in tissues in Cryopyrin-Associated Periodic Syndrome were promoted by the extracellular presence of the inflammasome adaptor protein ASC, opening exciting new directions in clinical practice to obtain a novel therapy towards secondary amyloidosis in inflammasomopathies. [Image: see text]

Keywords
amyloid，CD14，Cryopyrin-Associated Periodic Syndrome

Связанные продукты

Каталожный номер	Название продукта	Описание	Цель
HY038327	CD14	Anti-Human CD14 Recombinant Antibody (F1031), PE (HY038327) is a human monoclonal antibody detecting CD14 in ELISA, FCM, WB. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications. ●PE Conjugated — Ready for direct detection without secondary antibody.	CD14, Monocyte differentiation antigen CD14, Monocyte differentiation antigen CD14, membrane-bound form, Monocyte differentiation antigen CD14, urinary form, My23 antigen, Myeloid cell-specific leucine-rich glycoprotein

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The inflammasome adaptor protein ASC promotes amyloid deposition in cryopyrin-associated periodic syndromes

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