IgE & Anti-IgE Research Reagents

Total IgE Detection — Anti-human IgE antibodies (capture and detection pairs) for quantitative total IgE immunoassays. Total IgE is elevated in allergic disease, parasitic infections, hyper-IgE syndrome, and ABPA. Matched antibody pairs targeting the Cε3 domain of IgE heavy chain are essential for sandwich ELISA, CLIA, and lateral flow total IgE assay development.
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Recombinant IgE — Full-length and Fc-fragment recombinant human IgE proteins for immunoassay calibration, FcεRI binding studies, and anti-IgE drug characterization. IgE calibrator proteins must be free of IgG contamination and calibrated against WHO International Standard (NIBSC 75/502) for quantitative traceability.
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Anti-IgE (Omalizumab Biosimilar) — Research-grade anti-IgE monoclonal antibody based on the omalizumab sequence. Omalizumab binds the Cε3 domain of IgE at the same site as FcεRI, preventing IgE from binding to mast cells and basophils without crosslinking receptor-bound IgE. Research biosimilar formats support anti-IgE mechanism studies, PK/ADA assay development, and biosimilar comparability testing.
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1. Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol. 2008;8(3):205-217. DOI

2. Normansell R, et al. Omalizumab for asthma in adults and children. Cochrane Database Syst Rev. 2014;(1):CD003559. DOI