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| カタログ番号 | HC535014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| アイソタイプ | IgG | ||||||||
| クローン性 | Polyclonal | ||||||||
| 免疫原 | E. coli - derived recombinant Human KCNH2/ERG1 (Pro10-Lys135). | ||||||||
| ターゲット | H-ERG, ERG, HERG, hERG1, hERG-1, Potassium voltage-gated channel subfamily H member 2, ERG-1, KCNH2, Eag homolog, ERG1, Eag-related protein 1, Ether-a-go-go-related gene potassium channel 1, Voltage-gated potassium channel subunit Kv11.1, Ether-a-go-go-related protein 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q12809 | ||||||||
| RRID | Anti-Human KCNH2/ERG1 Polyclonal Antibody (abinScience Cat# HC535014, RRID:AB_3723263) |
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| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Voltage-gated inwardly rectifying potassium channel KCNH2 (ERG1) is a ~126 kDa protein. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity. 1. Abbott, GW. et al. (1999) Cell 97, 175-87. PMID: 10219239 2. Kagan, A. et al. (2000) The Journal of biological chemistry 275, 11241-8. PMID: 10753933 3. Paulussen, A. et al. (2000) Human mutation 15, 483. PMID: 10790218 4. Cui, J. et al. (2000) Current biology : CB 10, 671-4. PMID: 10837251 5. Yang, P. et al. (2002) Circulation 105, 1943-8. PMID: 11997281 6. Gong, Q. et al. (2002) American journal of physiology. Heart and circulatory physiology 283, H77-84. PMID: 12063277 7. Guasti, L. et al. (2008) Molecular and cellular biology 28, 5043-60. PMID: 18559421 8. Aidery, P. et al. (2012) Biochemical and biophysical research communications 418, 830-5. PMID: 22314138 9. Ng, CA. et al. (2012) PloS one 7, e31640. PMID: 22359612 10. Kang, Y. et al. (2015) The Biochemical journal 472, 71-82. PMID: 26363003 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-KCNH2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
Lane 2: 293T cell lysate
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