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| カタログ番号 | HY286043 | ||||||
|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human CD340/ERBB2/HER2 Antibody (SAA2012) [SAA2012] (HY286043) is a human monoclonal antibody detecting ERBB2 in ELISA, FCM, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||
| アプリケーション | ELISA, FCM, WB | ||||||
| 宿主種 | Human | ||||||
| アイソタイプ | IgG1, kappa | ||||||
| クローンID | SAA2012 | ||||||
| クローン性 | Monoclonal | ||||||
| ターゲット | p185erbB2, HER2, NGL, Tyrosine kinase-type cell surface receptor HER2, NEU, MLN 19, Proto-oncogene Neu, MLN19, ERBB2, Proto-oncogene c-ErbB-2, CD340, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||||
| アクセッション番号 | P04626 | ||||||
| RRID | Anti-Human CD340/ERBB2/HER2 Antibody (SAA2012) (abinScience Cat# HY286043, RRID:AB_3727924) |
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| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS, pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 背景 | Receptor tyrosine-protein kinase erbB-2 (CD340/ERBB2) is a ~137 kDa protein. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. CD340 is the therapeutic target of trastuzumab (Herceptin) and trastuzumab deruxtecan (Enhertu). | ||||||
| 注意事項 | For research use only. |
Flow-cytometry using anti-human CD340 & ERBB3 antibody.HeLa cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD340 & ERBB3 antibody monoclonal antibody (Catalog # HY286043 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-human antibody (Catalog # HF690414) and cells analysed on a NovoCyte Flow Cytometer.
SDS-PAGE for Anti-Human CD340/ERBB2/HER2 Antibody (SAA2012).
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