Anti-Evolocumab Non-Neutralizing Recombinant Antibody (SAA2822) (AV275073)

Name: Anti-Evolocumab Non-Neutralizing Recombinant Antibody (SAA2822)
Brand: abinScience
SKU: AV275073
Price: 168 USD
Availability: InStock

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Спецификация:

50ug
100ug
1mg

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Каталожный номер	AV275073
Описание	Anti-Evolocumab Non-Neutralizing Recombinant Antibody (SAA2822) (AV275073) is a rabbit monoclonal antibody detecting Evolocumab in ELISA. Suitable for General. Highlights ●Affinity Purified — Minimal background and high purity for reliable results.
Реактивность видов	General
Применения	ELISA
Хозяинский вид	Rabbit
Клоональность	Monoclonal
Изотип	IgG
ID клона	SAA2822
Система экспрессии	Mammalian cells
Иммуноген	Evolocumab
Уровень эндотоксинов	< 10 EU/mg as determined by LAL method.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	CAS: 1256937-27-5
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Proprotein convertase subtilisin/kexin type 9 (Evolocumab) is a ~74 kDa protein. Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. 1. Poirier, S. et al. (2008) The Journal of biological chemistry 283, 2363-72. PMID: 18039658 2. Nassoury, N. et al. (2007) Traffic (Copenhagen, Denmark) 8, 718-32. PMID: 17461796 3. Fan, D. et al. (2008) Biochemistry 47, 1631-9. PMID: 18197702 4. Mayer, G. et al. (2008) The Journal of biological chemistry 283, 31791-801. PMID: 18799458 5. Chen, Y. et al. (2011) Biochemical and biophysical research communications 415, 515-8. PMID: 22074827 6. Jonas, MC. et al. (2008) EMBO reports 9, 916-22. PMID: 18660751
Примечание	For research use only.

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Bioactivity

Detects Evolocumab (Catalog No: HV275026) in indirect ELISA.

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Anti-Evolocumab Non-Neutralizing Recombinant Antibody (SAA2822).pdf

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Anti-Evolocumab Non-Neutralizing Recombinant Antibody (SAA2822) (AV275073)

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