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Anti-Sarilumab Neutralizing Recombinant Antibody (SAA2882) (AY583073)

Anti-Sarilumab Neutralizing Recombinant Antibody (SAA2882)
Anti-Sarilumab Neutralizing Recombinant Antibody (SAA2882)
Anti-Sarilumab Neutralizing Recombinant Antibody (SAA2882)
Anti-Sarilumab Neutralizing Recombinant Antibody (SAA2882)
Цена(USD):
Спецификация:
  • 50ug
  • 100ug
  • 1mg
Количество:
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  • Изображения

  • Ссылки

  • Даташит

  • SDS

Обзор
Каталожный номерAY583073
Описание
Anti-Sarilumab Neutralizing Recombinant Antibody (SAA2882) (AY583073) is a mouse monoclonal antibody detecting Sarilumab in ELISA. Suitable for General.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
Реактивность видовGeneral
ПримененияELISA
Хозяинский видMouse
КлоональностьMonoclonal
ИзотипIgG1
ID клонаSAA2882
Иммуноген Sarilumab
Уровень эндотоксинов < 10EU/mg
Чистота >95% as determined by SDS-PAGE.
Очистка Protein A/G purified from cell culture supernatant.
Номер доступа CAS: 1189541-98-7
Форма Liquid
Буфер хранения 0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон

Interleukin-6 receptor subunit alpha (Sarilumab) is a ~51 kDa protein. Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system.

1. Larsen, JV. et al. (2017) Molecular and cellular biology 37. PMID: 28265003
2. Kang, S. et al. (2019) Immunity 50, 1007-1023. PMID: 30995492
3. Spencer, S. et al. (2019) The Journal of experimental medicine 216, 1986-1998. PMID: 31235509
Примечание For research use only.
Изображения
  • Anti-Sarilumab Neutralizing Recombinant Antibody (SAA2882)

    Bioactivity

    Detects Sarilumab (Catalog No: HY583016) in indirect ELISA.

  • Anti-Sarilumab Neutralizing Recombinant Antibody (SAA2882)

    Bioactivity

    Blocks the binding of Sarilumab to IL6R.

Ссылки
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Рекомендация

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