Anti-Golimumab Neutralizing Recombinant Antibody (SAA2923) (AF879083)

Name: Anti-Golimumab Neutralizing Recombinant Antibody (SAA2923)
Brand: abinScience
SKU: AF879083
Price: 168 USD
Availability: InStock

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100ug
1mg

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Обзор

Каталожный номер	AF879083
Описание	Anti-Golimumab Neutralizing Recombinant Antibody (SAA2923) (AF879083) is a mouse monoclonal antibody detecting Golimumab in ELISA. Suitable for General. Highlights ●Affinity Purified — Minimal background and high purity for reliable results.
Реактивность видов	General
Применения	ELISA
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1
ID клона	SAA2923
Иммуноген	Golimumab
Уровень эндотоксинов	< 10EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	CAS: 476181-74-5
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Golimumab (Simponi®) is a human immunoglobulin G1? monoclonal antibody which is specific for pro-inflammatory cytokine, tumor necrosis factor-a (TNFa). In 2009, it was approved by FDA for the treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis in adult patients. Elevated levels of TNF are found in the synovial fluid of rheumatoid arthritis, including juvenile idiopathic arthritis, psoriatic arthritis, and ankylosing spondylitis patients and play an important role in both the pathologic inflammation and the joint destruction that are hallmarks of these diseases. Increased levels of TNF are also found in psoriasis (Ps) plaques. Golimumab binds to both the soluble and transmembrane bioactive forms of human TNF and prevent TNF from binding to its receptors and finally inhibits biological activity of TNF.
Примечание	For research use only.

Изображения

Bioactivity

Anti-Golimumab Neutralizing Recombinant Antibody (SAA2923) binds with Golimumab.
Bioactivity

Anti-Golimumab Neutralizing Recombinant Antibody (SAA2923) blocks Golimumab binds to TNF-alpha.