Anti-Tiragolumab Neutralizing Recombinant Antibody (SAA2971) (AS739013)

Name: Anti-Tiragolumab Neutralizing Recombinant Antibody (SAA2971)
Brand: abinScience
SKU: AS739013
Price: 168 USD
Availability: InStock

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50ug
100ug
1mg

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Каталожный номер	AS739013
Описание	Anti-Tiragolumab Neutralizing Recombinant Antibody (SAA2971) (AS739013) is a mouse monoclonal antibody detecting Tiragolumab in ELISA. Suitable for General. Highlights ●Affinity Purified — Minimal background and high purity for reliable results.
Реактивность видов	General
Применения	ELISA
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG1
ID клона	SAA2971
Иммуноген	Tiragolumab
Уровень эндотоксинов	< 10EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	CAS: 1918185-84-8
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	T-cell immunoreceptor with Ig and ITIM domains (Tiragolumab) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. 1. Yu, X. et al. (2009) Nature immunology 10, 48-57. PMID: 19011627 2. Liu, S. et al. (2013) Cell death and differentiation 20, 456-64. PMID: 23154388 3. Li, M. et al. (2014) The Journal of biological chemistry 289, 17647-57. PMID: 24817116 4. Reches, A. et al. (2020) Journal for immunotherapy of cancer 8. PMID: 32503945
Примечание	For research use only.

Изображения

Bioactivity

Anti-Tiragolumab Neutralizing Recombinant Antibody (SAA2971) binds with Tiragolumab.
Bioactivity

Anti-Tiragolumab Neutralizing Recombinant Antibody (SAA2971) blocks Tiragolumab binds to TIGIT.