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| カタログ番号 | HV388014 | ||||||
|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human FoxP3 Polyclonal Antibody (HV388014) is a rabbit polyclonal antibody detecting FoxP3 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||
| アプリケーション | ELISA, IHC, WB | ||||||
| 宿主種 | Rabbit | ||||||
| クローン性 | Polyclonal | ||||||
| アイソタイプ | IgG | ||||||
| 免疫原 | E. coli - derived recombinant Human FOXP3 (Ser304-Pro431). | ||||||
| ターゲット | FOXP3, Forkhead box protein P3, Forkhead box protein P3 41 kDa form, Forkhead box protein P3, C-terminally processed, IPEX, Scurfin | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 観測分子量 | 55 kDa | ||||||
| 精製 | Purified by antigen affinity column. | ||||||
| アクセッション番号 | Q9BZS1 | ||||||
| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||||
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. | ||||||
| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| 背景 | Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. 1. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532 2. Bandukwala, HS. et al. (2011) Immunity 34, 479-91. PMID: 21458306 3. Vent-Schmidt, J. et al. (2014) International reviews of immunology 33, 110-28. PMID: 23947341 4. Passerini, L. et al. (2014) International reviews of immunology 33, 129-45. PMID: 24354325 5. Ramsdell, F. et al. (2014) Nature reviews. Immunology 14, 343-9. PMID: 24722479 6. Xiao, Y. et al. (2014) Cell reports 7, 1471-1480. PMID: 24835996 7. Becher, J. et al. (2018) Developmental cell 47, 592-607.e6. PMID: 30513302 8. Yang, J. et al. (2020) EMBO reports 21, e50308. PMID: 32644293 9. McMurchy, AN. et al. (2013) Blood 121, 1265-75. PMID: 23169781 10. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681 | ||||||
| 注意事項 | For research use only. |
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