

| Numéro de catalogue | MV819014 | ||||||
|---|---|---|---|---|---|---|---|
| Description |
Anti-Mouse NANOG Polyclonal Antibody (MV819014) is a rabbit polyclonal antibody detecting NANOG in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Reactivité des espèces | Mouse | ||||||
| Applications | ELISA, IHC, WB | ||||||
| Espèce hôte | Rabbit | ||||||
| Clonalité | Polyclonal | ||||||
| Isotype | IgG | ||||||
| Immunogène | E. coli - derived recombinant Mouse NANOG (Thr101-Ile167). | ||||||
| Cible | ES cell-associated protein 4, Early embryo specific expression NK-type homeobox protein, Ecat4, Enk, Homeobox protein NANOG, Homeobox transcription factor Nanog, Nanog | ||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||
| Masse moléculaire observée | 37 kDa | ||||||
| Purification | Purified by antigen affinity column. | ||||||
| Numéro d'accès | Q80Z64 | ||||||
| Forme | Liquid | ||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||||
| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. | ||||||
| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| Contexte | Homeobox protein NANOG is a ~34 kDa protein. Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. 1. Hayashi, Y. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 4666-71. PMID: 25825768 | ||||||
| Note | For research use only. |
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