Insect Venom Allergen Research Reagents

Api m 1 (Honeybee Phospholipase A2) — The major honeybee (Apis mellifera) venom allergen, recognized by >95% of bee venom-allergic patients. Api m 1 is the key species-specific marker for bee venom allergy — its recombinant form (CCD-free) differentiates true bee sensitization from CCD-mediated cross-reactivity with wasp venom.
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Ves v 5 (Wasp Antigen 5) — The major Vespula vulgaris (yellow jacket) venom allergen. Ves v 5 is species-specific for Vespinae and does not cross-react with bee venom allergens. Combined testing of Api m 1 and Ves v 5 resolves >90% of bee-wasp double-positive cases, directly guiding single or dual VIT prescription.
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Vesp c 5 (Hornet Antigen 5) — The major allergen of Vespa crabro (European hornet). Vesp c 5 cross-reacts with Ves v 5 but not with bee venom, making the Vespinae-specific Antigen 5 family a useful diagnostic group for wasp/hornet venom allergy differentiation.
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1. Bilò MB, et al. EAACI position paper: diagnosis of Hymenoptera venom allergy. Allergy. 2005;60(11):1339-1349. DOI

2. Müller UR, et al. Component-resolved diagnosis of Hymenoptera venom allergy. Curr Opin Allergy Clin Immunol. 2009;9(4):346-351. DOI