

| Каталожный номер | MY071014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Mouse XRCC5/Ku80 Polyclonal Antibody (MY071014) is a rabbit polyclonal antibody detecting XRCC5/Ku80 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Реактивность видов | Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse XRCC5/Ku80 (Met1-Glu241). | ||||||||
| Цель | 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit, CTC85, CTCBF, DNA repair protein Ku80, DNA repair protein XRCC5, EC:4.2.99.18, EC:5.6.2.4, G22P2, Ku80, Ku86, Lupus Ku autoantigen protein p86, Nuclear factor IV, TLAA, Thyroid-lupus autoantigen, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining), X-ray repair cross-complementing protein 5, XRCC5 | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P27641 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | DNA repair protein Ku80 (XRCC5) is a ~82 kDa protein. DNA-binding protein critical for the DNA damage response, specifically in repairing double-strand breaks (DSBs) via the classical non-homologous end joining (NHEJ) pathway. It forms a heterodimer with XRCC6 (Ku70), creating the Ku70:Ku80 heterodimer (Ku complex), which serves as a DNA end-binding complex. It primarily binds DSBs and recruits essential repair factors, assembling the core long-range NHEJ complex to facilitate the alignment and ligation of broken DNA ends. This pathway ensures the rapid repair of cytotoxic and mutagenic DSBs and contributes to the generation of diversity in T-cell receptors and antibodies through mechanisms such as V(D)J recombination. Likely acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), catalyzing the beta-elimination of the 5'-deoxyribose-5-phosphate at abasic sites near DSBs. 1. Walker, JR. et al. (2001) Nature 412, 607-14. PMID: 11493912 2. Chen, S. et al. (2021) Nature 593, 294-298. PMID: 33854234 3. Chaplin, AK. et al. (2021) Molecular cell 81, 3400-3409.e3. PMID: 34352203 4. West, RB. et al. (1998) Molecular and cellular biology 18, 5908-20. PMID: 9742108 5. Roberts, SA. et al. (2010) Nature 464, 1214-7. PMID: 20383123 6. Tuteja, N. et al. (1994) The EMBO journal 13, 4991-5001. PMID: 7957065 7. Maekawa, T. et al. (2018) Nucleic acids research 46, 4487-4504. PMID: 29490055 8. Willis, DM. et al. (2002) The Journal of biological chemistry 277, 37280-91. PMID: 12145306 9. Chung, U. et al. (1996) The Journal of biological chemistry 271, 8593-8. PMID: 8621488 10. Morchikh, M. et al. (2017) Molecular cell 67, 387-399.e5. PMID: 28712728 | ||||||||
| Примечание | For research use only |
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