Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody (MW574014)

Name: Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody
Brand: abinScience
SKU: MW574014
Price: 168 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

MW574014

Descripción

Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody (MW574014) is a rabbit polyclonal antibody detecting CHOP/GADD153/DDIT3 in ELISA, IHC, WB. Suitable for Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Mouse CHOP/GADD153/DDIT3 (Met1-Ala168).

Objetivo

C/EBP zeta, C/EBP-homologous protein, C/EBP-homologous protein 10, CCAAT/enhancer-binding protein homologous protein, CHOP, CHOP-10, CHOP10, DDIT-3, DDIT3, DNA damage-inducible transcript 3 protein, GADD153, Growth arrest and DNA damage-inducible protein GADD153

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P35639

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Fondo

DNA damage-inducible transcript 3 protein (CHOP/GADD153) is a ~19 kDa protein. Multifunctional transcription factor in endoplasmic reticulum (ER) stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.

1. Yamaguchi, H. et al. (2004) The Journal of biological chemistry 279, 45495-502. PMID: 15322075

2. Ohoka, N. et al. (2005) The EMBO journal 24, 1243-55. PMID: 15775988

3. Oliveira, SJ. et al. (2009) PloS one 4, e6618. PMID: 19672300

4. Vij, N. et al. (2008) American journal of respiratory cell and molecular biology 38, 176-84. PMID: 17709599

5. Goodall, JC. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 17698-703. PMID: 20876114

6. Ghosh, AP. et al. (2012) PloS one 7, e39586. PMID: 22761832

7. Su, N. et al. (2008) The Journal of biological chemistry 283, 35106-17. PMID: 18940792

8. Park, SH. et al. (2010) The Journal of biological chemistry 285, 35330-9. PMID: 20829347

Nota

For research use only

Imágenes

Referencias

Datasheet

Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo