Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody (MW574014)

Name: Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody
Brand: abinScience
SKU: MW574014
Price: 168 USD
Availability: InStock

Fiche technique Partager le produit Copier les informations

Prix(USD) :

Spécification :

50ug
100ug

Nombre :

Contactez-nous

Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

MW574014

Description

Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody (MW574014) is a rabbit polyclonal antibody detecting CHOP/GADD153/DDIT3 in ELISA, IHC, WB. Suitable for Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Mouse CHOP/GADD153/DDIT3 (Met1-Ala168).

Cible

C/EBP zeta, C/EBP-homologous protein, C/EBP-homologous protein 10, CCAAT/enhancer-binding protein homologous protein, CHOP, CHOP-10, CHOP10, DDIT-3, DDIT3, DNA damage-inducible transcript 3 protein, GADD153, Growth arrest and DNA damage-inducible protein GADD153

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

P35639

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

DNA damage-inducible transcript 3 protein (CHOP/GADD153) is a ~19 kDa protein. Multifunctional transcription factor in endoplasmic reticulum (ER) stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.

1. Yamaguchi, H. et al. (2004) The Journal of biological chemistry 279, 45495-502. PMID: 15322075

2. Ohoka, N. et al. (2005) The EMBO journal 24, 1243-55. PMID: 15775988

3. Oliveira, SJ. et al. (2009) PloS one 4, e6618. PMID: 19672300

4. Vij, N. et al. (2008) American journal of respiratory cell and molecular biology 38, 176-84. PMID: 17709599

5. Goodall, JC. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 17698-703. PMID: 20876114

6. Ghosh, AP. et al. (2012) PloS one 7, e39586. PMID: 22761832

7. Su, N. et al. (2008) The Journal of biological chemistry 283, 35106-17. PMID: 18940792

8. Park, SH. et al. (2010) The Journal of biological chemistry 285, 35330-9. PMID: 20829347

Note

For research use only

Images

Reférences

Fiche technique

Anti-Mouse CHOP/GADD153/DDIT3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai