Anti-Mouse NR1H4/FXR Polyclonal Antibody (MV836014)

Name: Anti-Mouse NR1H4/FXR Polyclonal Antibody
Brand: abinScience
SKU: MV836014
Price: 168 USD
Availability: InStock

Даташит Поделиться продуктом Копировать информацию

Цена(USD): --

Спецификация:

50ug
100ug

Количество:

Свяжитесь с нами

Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

MV836014

Описание

Anti-Mouse NR1H4/FXR Polyclonal Antibody (MV836014) is a rabbit polyclonal antibody detecting NR1H4/FXR in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Mouse NR1H4/FXR (Leu261-Gln488).

Цель

BAR, Bile acid receptor, FXR, Farnesoid X-activated receptor, Farnesol receptor HRR-1, HRR1, NR1H4, Nuclear receptor subfamily 1 group H member 4, RIP14, RXR-interacting protein 14, Retinoid X receptor-interacting protein 14

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

Q60641

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Фон

Bile acid receptor (NR1H4/FXR) is a ~55 kDa protein. Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands.

1. Makishima, M. et al. (1999) Science (New York, N.Y.) 284, 1362-5. PMID: 10334992

2. Parks, DJ. et al. (1999) Science (New York, N.Y.) 284, 1365-8. PMID: 10334993

3. Modica, S. et al. (2010) Nuclear receptor signaling 8, e005. PMID: 21383957

4. Hollman, DA. et al. (2012) Biochimica et biophysica acta 1821, 1443-52. PMID: 22820415

5. Pircher, PC. et al. (2003) The Journal of biological chemistry 278, 27703-11. PMID: 12754200

6. Ananthanarayanan, M. et al. (2004) The Journal of biological chemistry 279, 54348-57. PMID: 15471871

7. Sanyal, S. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 15665-70. PMID: 17895379

8. Grober, J. et al. (1999) The Journal of biological chemistry 274, 29749-54. PMID: 10514450

9. Neimark, E. et al. (2004) Hepatology (Baltimore, Md.) 40, 149-56. PMID: 15239098

10. Landrier, JF. et al. (2006) American journal of physiology. Gastrointestinal and liver physiology 290, G476-85. PMID: 16269519

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-Mouse NR1H4/FXR Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Mouse NR1H4/FXR Polyclonal Antibody (MV836014)

Обзор

Изображения

Ссылки

Даташит

SDS