Anti-Mouse Integrin beta 6/ITGB6 Polyclonal Antibody (MB251014)

Name: Anti-Mouse Integrin beta 6/ITGB6 Polyclonal Antibody
Brand: abinScience
SKU: MB251014
Price: 168 USD
Availability: InStock

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50ug
100ug

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SDS

Aperçu

Numéro de catalogue

MB251014

Description

Anti-Mouse Integrin beta 6/ITGB6 Polyclonal Antibody (MB251014) is a rabbit polyclonal antibody detecting Integrin beta 6/ITGB6 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Mouse ITGB6 (Tyr131-Ser373).

Cible

ITGB6, Integrin beta-6

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9Z0T9

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

Integrin beta-6 (ITGB6) is a ~85 kDa protein. Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation.

1. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881

2. Ramsay, AG. et al. (2007) Cancer research 67, 5275-84. PMID: 17545607

3. Annes, JP. et al. (2004) The Journal of cell biology 165, 723-34. PMID: 15184403

4. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742

5. Dong, X. et al. (2017) Nature 542, 55-59. PMID: 28117447

Note

For research use only

Images

Reférences

Fiche technique

Anti-Mouse Integrin beta 6/ITGB6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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