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Anti-Mouse Perforin Polyclonal Antibody (MB886014)

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Vista general
Número de catálogoMB886014
Descripción
Anti-Mouse Perforin Polyclonal Antibody (MB886014) is a rabbit polyclonal antibody detecting Perforin in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesMouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Mouse Perforin (Leu413-Trp554).
Objetivo Cytolysin, Lymphocyte pore-forming protein, P1, PFP, PRF1, Perforin-1
Nivel de endotoxinas Please contact with the lab for this information.
Pureza >95% as determined by SDS-PAGE.
Purificación Purified by antigen affinity column.
Número de acceso P10820
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Perforin-1 is a ~61 kDa protein. Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes.

1. Praper, T. et al. (2011) The Journal of biological chemistry 286, 2946-55. PMID: 20889983
2. Law, RH. et al. (2010) Nature 468, 447-51. PMID: 21037563
3. Stewart, SE. et al. (2014) The Journal of biological chemistry 289, 9172-81. PMID: 24558045
4. Vergelli, M. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 158, 2756-61. PMID: 9058810
5. Ando, K. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 158, 5283-91. PMID: 9164947
6. Thiery, J. et al. (2010) Blood 115, 1582-93. PMID: 20038786
7. Czystowska, M. et al. (2010) Journal of molecular medicine (Berlin, Germany) 88, 577-88. PMID: 20225066
8. Zhou, Z. et al. (2020) Science (New York, N.Y.) 368. PMID: 32299851
Nota For research use only
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Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Mouse Perforin Polyclonal Antibody

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