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Anti-Mouse IRF5 Polyclonal Antibody (MC523014)

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Vista general
Número de catálogoMC523014
Descripción
Anti-Mouse IRF5 Polyclonal Antibody (MC523014) is a rabbit polyclonal antibody detecting IRF5 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Mouse IRF5 (Leu246-Gly431).
Objetivo IRF-5, IRF5, Interferon regulatory factor 5
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P56477
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Interferon regulatory factor 5 (IRF5) is a ~56 kDa protein. Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway. Key transcription factor regulating the IFN response during SARS-CoV-2 infection.

1. Barnes, BJ. et al. (2001) The Journal of biological chemistry 276, 23382-90. PMID: 11303025
2. Schoenemeyer, A. et al. (2005) The Journal of biological chemistry 280, 17005-12. PMID: 15695821
3. Chang Foreman, HC. et al. (2012) PloS one 7, e33098. PMID: 22412986
4. Lopez-Pelaez, M. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 17432-7. PMID: 25326418
5. Heinz, LX. et al. (2020) Nature 581, 316-322. PMID: 32433612
6. Yin, X. et al. (2021) Cell reports 34, 108628. PMID: 33440148
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Mouse IRF5 Polyclonal Antibody

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