

| Número de catálogo | ZY164014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-African clawed frog IRF1 Polyclonal Antibody (ZY164014) is a rabbit polyclonal antibody detecting IRF1 in ELISA, IHC, WB. Suitable for Xenopus laevis (African clawed frog).
Highlights
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| Reactividad de especies | Xenopus laevis (African clawed frog) | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant African clawed frog IRF1 (Met1-Arg124). | ||||||||
| Objetivo | IRF-1, IRF1, Interferon regulatory factor 1 | ||||||||
| Nivel de endotoxinas | Please contact with the lab for this information. | ||||||||
| Pureza | >95% as determined by SDS-PAGE. | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q6PB00 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Fondo | Interferon regulatory factor 1 (IRF1) is a ~36 kDa protein. Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Has an essentail role in IFNG-dependent immunity to mycobacteria. Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters. 1. Oshima, S. et al. (2004) Molecular and cellular biology 24, 6298-310. PMID: 15226432 2. Dornan, D. et al. (2004) Molecular and cellular biology 24, 10083-98. PMID: 15509808 3. Su, ZZ. et al. (2007) Journal of cellular physiology 213, 502-10. PMID: 17516545 4. Park, J. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 17028-33. PMID: 17942705 5. Bowie, ML. et al. (2008) Advances in experimental medicine and biology 617, 367-74. PMID: 18497060 6. Huang, Y. et al. (2009) PloS one 4, e5397. PMID: 19404407 7. Gao, J. et al. (2010) Cell death and differentiation 17, 699-709. PMID: 19851330 8. Qi, H. et al. (2012) The Journal of biological chemistry 287, 12622-33. PMID: 22367195 9. Somerville, TDD. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 11471-11482. PMID: 32385160 10. Tanaka, N. et al. (1993) Molecular and cellular biology 13, 4531-8. PMID: 7687740 | ||||||||
| Nota | For research use only |
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