Please ensure Javascript is enabled for purposes of website accessibility
Contáctenos Contáctenos
ES
Inicio > Productos > Anticuerpos > Anticuerpos Primarios

Anti-Mouse PXDN Polyclonal Antibody (MV750014)

Datasheet Compartir producto Copiar información
Precio(USD):
Especificación:
  • 50ug
  • 100ug
Número:
Contáctenos

  • Vista general

  • Imágenes

  • Referencias

  • Datasheet

  • SDS

Vista general
Número de catálogoMV750014
Descripción
Anti-Mouse PXDN Polyclonal Antibody (MV750014) is a rabbit polyclonal antibody detecting PXDN in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Mouse PXDN (Cys37-Asp194).
Objetivo EC:1.11.2.-, KIAA0230, MG50, Melanoma-associated antigen MG50, PRG2, PXD01, PXDN, PXDN active fragment, Peroxidasin 1, Peroxidasin homolog, VPO, VPO1, Vascular peroxidase 1, hsPxd01, p53-responsive gene 2 protein
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q3UQ28
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Peroxidasin homolog (PXDN) is a ~165 kDa protein. Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer. In turns, directly contributes to the collagen IV network-dependent fibronectin/FN and laminin assembly, which is required for full extracellular matrix (ECM)-mediated signaling. Thus, sulfilimine cross-links are essential for growth factor-induced cell proliferation and survival in endothelial cells, an event essential to basement membrane integrity. In addition, through the bromide oxidation, may promote tubulogenesis and induce angiogenesis through ERK1/2, Akt, and FAK pathways. Moreover brominates alpha2 collagen IV chain/COL4A2 at 'Tyr-1485' and leads to bromine enrichment of the basement membranes.

1. Cheng, G. et al. (2008) Free radical biology & medicine 45, 1682-94. PMID: 18929642
2. Péterfi, Z. et al. (2009) The American journal of pathology 175, 725-35. PMID: 19590037
3. Bhave, G. et al. (2012) Nature chemical biology 8, 784-90. PMID: 22842973
4. Lázár, E. et al. (2015) Free radical biology & medicine 83, 273-82. PMID: 25708780
5. Soudi, M. et al. (2015) The Journal of biological chemistry 290, 10876-90. PMID: 25713063
6. Colon, S. et al. (2016) The Journal of biological chemistry 291, 24009-24016. PMID: 27697841
7. Paumann-Page, M. et al. (2017) The Journal of biological chemistry 292, 4583-4592. PMID: 28154175
8. Kovács, HA. et al. (2021) Antioxidants (Basel, Switzerland) 10. PMID: 34679700
9. Lee, SW. et al. (2020) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34, 10228-10241. PMID: 32543734
10. He, C. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 15827-15836. PMID: 32571911
Nota For research use only
Imágenes
Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Recomendación

Contáctenos para cotizaciones personalizadas, solicitudes en masa y cualquier otro problema.

Correo: [email protected]

Lista de distribuidores

Obtener una cotización gratuita
Anti-Mouse PXDN Polyclonal Antibody

Acceso rápido

Contáctenos

  • +86-027-65523339

  • [email protected]

  • Edificio C, No. 666, Calle Shendunsi, Wuhan, 430206, China

  • linkedin
  • Ins
  • youtube
  • youtube
Derechos de autor © 2026 abinScience. Todos los derechos reservados. Todos los productos son solo para uso de investigación