Anti-Mouse IRF8 Polyclonal Antibody (MX047014)

Name: Anti-Mouse IRF8 Polyclonal Antibody
Brand: abinScience
SKU: MX047014
Price: 168 USD
Availability: InStock

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100ug

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SDS

Aperçu

Numéro de catalogue

MX047014

Description

Anti-Mouse IRF8 Polyclonal Antibody (MX047014) is a rabbit polyclonal antibody detecting IRF8 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Mouse IRF8 (Ser200-Gly386).

Cible

H-ICSBP, ICSBP, ICSBP1, IRF-8, IRF8, Interferon consensus sequence-binding protein, Interferon regulatory factor 8

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

P23611

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

Interferon regulatory factor 8 (IRF8) is a ~48 kDa protein. Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor. Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection.

1. Salem, S. et al. (2014) Blood 124, 1894-904. PMID: 25122610

2. Agod, Z. et al. (2018) Frontiers in immunology 9, 62. PMID: 29434592

Note

For research use only

Images

Reférences

Fiche technique

Anti-Mouse IRF8 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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