

| Каталожный номер | MS702014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Mouse MPEG1 Polyclonal Antibody (MS702014) is a rabbit polyclonal antibody detecting MPEG1 in ELISA, IHC, WB. Suitable for Mouse, Rat.
Highlights
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| Реактивность видов | Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse MPEG1 (Gly379-Lys576). | ||||||||
| Цель | MPEG1, Macrophage gene 1 protein, Macrophage-expressed gene 1 protein, Macrophage-expressed gene 1 protein, processed form, Mpg-1, P-2, Perforin-2 | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | A1L314 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | Macrophage-expressed gene 1 protein (MPEG1) is a ~78 kDa protein. Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide. 1. Fields, KA. et al. (2013) Infection and immunity 81, 3045-54. PMID: 23753625 2. McCormack, RM. et al. (2015) eLife 4. PMID: 26402460 3. McCormack, RM. et al. (2017) JCI insight 2. PMID: 28422754 4. Strbo, N. et al. (2019) Experimental dermatology 28, 225-232. PMID: 30609079 5. Pang, SS. et al. (2019) Nature communications 10, 4288. PMID: 31537793 6. Merselis, LC. et al. (2020) Frontiers in immunology 11, 601584. PMID: 33224153 | ||||||||
| Примечание | For research use only |
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