

| Каталожный номер | MC495014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Mouse CYP24A1 Polyclonal Antibody (MC495014) is a rabbit polyclonal antibody detecting CYP24A1 in ELISA, IHC, WB. Suitable for Mouse, Rat.
Highlights
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| Реактивность видов | Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse CYP24A1 (Ser69-Arg514). | ||||||||
| Цель | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial, 24-OHase, CYP24, CYP24A1, Cytochrome P450 24A1, Cytochrome P450-CC24, EC:1.14.15.16, Vitamin D(3) 24-hydroxylase | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q64441 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) is a ~58 kDa protein. A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24-oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. With initial hydroxylation at C-23 (via C23-oxidation pathway), catalyzes sequential oxidation of calcidiol leading to the formation of 25(OH)D3-26,23-lactone as end product. Preferentially hydroxylates at C-25 other vitamin D active metabolites, such as CYP11A1-derived secosteroids 20S-hydroxycholecalciferol and 20S,23-dihydroxycholecalciferol. 1. Sakaki, T. et al. (2000) European journal of biochemistry 267, 6158-65. PMID: 11012668 2. Sakaki, T. et al. (2005) Frontiers in bioscience : a journal and virtual library 10, 119-34. PMID: 15574355 3. Hamamoto, H. et al. (2006) Molecular pharmacology 70, 120-8. PMID: 16617161 4. Tieu, EW. et al. (2014) The FEBS journal 281, 3280-96. PMID: 24893882 5. Roizen, JD. et al. (2018) The Journal of clinical investigation 128, 1913-1918. PMID: 29461981 6. Beckman, MJ. et al. (1996) Biochemistry 35, 8465-72. PMID: 8679605 | ||||||||
| Примечание | For research use only. |
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