

| Каталожный номер | VK698013 | ||||
|---|---|---|---|---|---|
| Описание |
Anti-JCPyV Major capsid protein VP1 Recombinant Antibody (SAA3058) (VK698013) is a human monoclonal antibody detecting Major capsid protein VP1 in ELISA, Neutralizing, Blocking. Suitable for JC polyomavirus (JCPyV/JCV), BK polyomavirus (BKPyV).
Highlights
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| Реактивность видов | JC polyomavirus (JCPyV/JCV), BK polyomavirus (BKPyV) | ||||
| Применения | ELISA, Neutralizing, Blocking | ||||
| Хозяинский вид | Human | ||||
| Клоональность | Monoclonal | ||||
| Изотип | IgG | ||||
| ID клона | SAA3058 | ||||
| Цель | Major capsid protein VP1, Major structural protein VP1 | ||||
| Уровень эндотоксинов | < 10 EU/mg as determined by LAL method. | ||||
| Чистота | >95% as determined by SDS-PAGE. | ||||
| Очистка | Protein A/G purified from cell culture supernatant. | ||||
| Номер доступа | P03089, P03088 | ||||
| Форма | Liquid | ||||
| Буфер хранения | 0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Реконституция | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||
| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Фон | Major capsid protein VP1 is a ~40 kDa protein. Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with gangliosides GT1b and GD1b containing terminal alpha(2-8)-linked sialic acids on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. | ||||
| Примечание | For research use only. |
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