Anti-Human MICL/CLEC12A Recombinant Antibody (CLT030) (HV493013)

Name: Anti-Human MICL/CLEC12A Recombinant Antibody (CLT030)
Brand: abinScience
SKU: HV493013
Price: 191 USD
Availability: InStock

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Спецификация:

50ug
100ug
1mg

Количество:

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SDS

Обзор

Каталожный номер

HV493013

Описание

Anti-Human MICL/CLEC12A Recombinant Antibody (CLT030) (HV493013) is a human monoclonal antibody detecting MICL/CLEC12A in ELISA. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.

Реактивность видов

Human

Применения

ELISA

Хозяинский вид

Human

Клоональность

Monoclonal

Изотип

IgG1, kappa

ID клона

CLT030

Цель

C-type lectin domain family 12 member A, C-type lectin-like molecule 1, CD371, CLEC12A, CLL-1, CLL1, DCAL-2, DCAL2, Dendritic cell-associated lectin 2, KLRL1, Killer cell C-type lectin-like receptor L1, MICL, Myeloid inhibitory C-type lectin-like receptor, hKLRL1

Уровень эндотоксинов

< 10 EU/mg

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

Q5QGZ9

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

C-type lectin domain family 12 member A (CD371/CLEC12A) is a ~30 kDa protein. Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation.

1. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280

2. Han, Y. et al. (2004) Blood 104, 2858-66. PMID: 15238421

3. Chen, CH. et al. (2006) Blood 107, 1459-67. PMID: 16239426

4. Paré, G. et al. (2021) Frontiers in immunology 12, 650808. PMID: 34234773

5. Tang, H. et al. (2024) The Journal of biological chemistry 300, 105765. PMID: 38367667

6. Mori, S. et al. (2024) International immunology 36, 279-290. PMID: 38386511

7. Malamud, M. et al. (2024) Nature 633, 442-450. PMID: 39143217

Примечание

For research use only

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