InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25) (MY408010)

Name: InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25)
Brand: abinScience
SKU: MY408010
Price: 191 USD
Availability: InStock

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Número de catálogo	MY408010
Descripción	InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25) (MY408010) is a mouse monoclonal antibody detecting IL-7 in in vivo IL-7 neutralization; in vivo IL-7 receptor stimulation. Suitable for Human, Mouse. Highlights ●Affinity Purified — Minimal background and high purity for reliable results. ●Multi-Application — Validated across multiple applications. ●Multi-Species — Cross-reactive for translational research.
Reactividad de especies	Human, Mouse
Aplicaciones	in vivo IL-7 neutralization; in vivo IL-7 receptor stimulation
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2b, kappa
ID de clon	M25
Objetivo	IL-7, Il-7, Il7, Interleukin-7
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P10168
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Interleukin-7 (IL7) is a ~20 kDa protein. Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5. 1. Bazdar, DA. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 4698-704. PMID: 25870237 2. Dittel, BN. et al. (1995) Journal of immunology (Baltimore, Md. : 1950) 154, 58-67. PMID: 7527823 3. Kondo, M. et al. (1994) Science (New York, N.Y.) 263, 1453-4. PMID: 8128231 4. Johnson, SE. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 8109-17. PMID: 18523275 5. Rochman, Y. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 19455-60. PMID: 20974963
Nota	For research use only

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InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25).pdf

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