InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25) (MY408010)

Name: InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25)
Brand: abinScience
SKU: MY408010
Price: 191 USD
Availability: InStock

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Numéro de catalogue	MY408010
Description	InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25) (MY408010) is a mouse monoclonal antibody detecting IL-7 in in vivo IL-7 neutralization; in vivo IL-7 receptor stimulation. Suitable for Human, Mouse. Highlights ●Affinity Purified — Minimal background and high purity for reliable results. ●Multi-Application — Validated across multiple applications. ●Multi-Species — Cross-reactive for translational research.
Reactivité des espèces	Human, Mouse
Applications	in vivo IL-7 neutralization; in vivo IL-7 receptor stimulation
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2b, kappa
ID de clone	M25
Cible	IL-7, Il-7, Il7, Interleukin-7
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P10168
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Interleukin-7 (IL7) is a ~20 kDa protein. Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5. 1. Bazdar, DA. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 4698-704. PMID: 25870237 2. Dittel, BN. et al. (1995) Journal of immunology (Baltimore, Md. : 1950) 154, 58-67. PMID: 7527823 3. Kondo, M. et al. (1994) Science (New York, N.Y.) 263, 1453-4. PMID: 8128231 4. Johnson, SE. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 8109-17. PMID: 18523275 5. Rochman, Y. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 19455-60. PMID: 20974963
Note	For research use only

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InVivoMAb Anti-Mouse/Human IL-7 Antibody (M25).pdf

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