中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HY039016 |
|---|---|
| 説明 |
Anti-HLA-A2-peptide (HMTEVVRHC) Complex & CD3 epsilon Reference Antibody (Graxutamig, RUO) (HY039016) is a monoclonal antibody detecting p53.
|
| 種反応性 | Human |
| アプリケーション | ELISA, FCM, Functional assay |
| クローン性 | Monoclonal |
| アイソタイプ | SCFV-SCFV-Fc |
| クローンID | Graxutamig |
| 発現システム | Mammalian cells |
| 性質 | Recombinant |
| ターゲット | TP53-target gene 5 protein, TP53-inducible gene 5 protein, TP53TG5, C20orf10, T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E |
| エンドトキシンレベル | < 10 EU/mg as determined by LAL method. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q9Y2B4 & P07766 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt.. |
| 別名 | CAS: 3081136-73-1 |
| 背景 | Cellular tumor antigen p53 (TP53) is a ~43 kDa protein. Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. 1. Guo, A. et al. (2000) Nature cell biology 2, 730-6. PMID: 11025664 2. Bergamaschi, D. et al. (2003) Nature genetics 33, 162-7. PMID: 12524540 3. Louria-Hayon, I. et al. (2003) The Journal of biological chemistry 278, 33134-41. PMID: 12810724 4. An, W. et al. (2004) Cell 117, 735-48. PMID: 15186775 5. Ghosh, A. et al. (2004) Molecular and cellular biology 24, 7987-97. PMID: 15340061 6. Zhao, Y. et al. (2007) The Journal of biological chemistry 282, 11969-81. PMID: 17317671 7. Taira, N. et al. (2007) Molecular cell 25, 725-38. PMID: 17349958 8. Allton, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 11612-6. PMID: 19556538 9. Huarte, M. et al. (2010) Cell 142, 409-19. PMID: 20673990 10. Wu, L. et al. (2011) The Journal of biological chemistry 286, 2236-44. PMID: 20959462 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
