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Anti-Human CD35 Reference Antibody (Ledacocept, RUO) (HB625016)

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  • 100ug
  • 1mg
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Vista general
Número de catálogoHB625016
Descripción
Anti-Human CD35 Reference Antibody (Ledacocept, RUO) (HB625016) is a monoclonal antibody detecting CD35.
Reactividad de especiesHuman
AplicacionesELISA, FCM, Functional assay
ClonalidadMonoclonal
IsotipoCD35
Sistema de expresión Mammalian cells
Naturaleza Recombinant
Objetivo C3BR, C3b/C4b receptor, CD35, CR1, Complement receptor type 1
Nivel de endotoxinas < 10 EU/mg as determined by LAL method.
Pureza >95% as determined by SDS-PAGE.
Purificación Protein A/G purified from cell culture supernatant.
Número de acceso P17927
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..
Nombres alternativosCAS: 3083227-23-7
Fondo

Complement receptor type 1 (CD35/CR1) is a ~223 kDa protein. Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells.

1. Schifferli, JA. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 140, 899-904. PMID: 2963069
2. Klickstein, LB. et al. (1988) The Journal of experimental medicine 168, 1699-717. PMID: 2972794
3. Krych, M. et al. (1994) The Journal of biological chemistry 269, 13273-8. PMID: 8175757
4. Török, K. et al. (2015) Immunology letters 164, 117-24. PMID: 25742728
Nota For research use only. Not suitable for clinical or therapeutic use.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human CD35 Reference Antibody (Ledacocept, RUO)

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